Combined antitumor activity of the nitroreductase/CB1954 suicide gene system and γ-rays in HeLa cells in vitro

Escherichia coli nitroreductase (NTR) may convert the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent, which may lead to DNA crosslinks and the apoptosis of cancer cells. NTR/CB1954 has been demonstrated to be an effective gene therapy in cancer cells. Th...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Mol Med Rep
Hlavní autoři: Teng, Geling, Ju, Yuanrong, Yang, Yepeng, Hua, Hu, Chi, Jingyu, Mu, Xiuan
Médium: Artigo
Jazyk:Inglês
Vydáno: D.A. Spandidos 2016
Témata:
Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355654/
https://ncbi.nlm.nih.gov/pubmed/27840931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2016.5917
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky