2-Amino metabolites are key mediators of CB 1954 and SN 23862 bystander effects in nitroreductase GDEPT

An important feature of gene-directed enzyme-prodrug therapy is that prodrug activation can provide diffusible cytotoxic metabolites capable of generating a local bystander effect in tumours. Activation of the aziridinyl dinitrobenzamide CB 1954 by E. coli nitroreductase (NTR) provides a bystander e...

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Detalhes bibliográficos
Main Authors: Helsby, N A, Ferry, D M, Patterson, A V, Pullen, S M, Wilson, W R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2004
Assuntos:
Experimental Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2409616/
https://ncbi.nlm.nih.gov/pubmed/14997211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601612
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