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An EGFR inhibitor enhances the efficacy of SN38, an active metabolite of irinotecan, in SN38-refractory gastric carcinoma cells

BACKGROUND: Acquired drug resistance to irinotecan is one of the significant obstacles in the treatment of advanced gastric cancer. This study was performed to clarify the effect of epidermal growth factor receptor (EGFR) inhibitors in combination with SN38, an active metabolite of irinotecan, on th...

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Detalhes bibliográficos
Main Authors: Yashiro, M, Qiu, H, Hasegawa, T, Zhang, X, Matsuzaki, T, Hirakawa, K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3242520/
https://ncbi.nlm.nih.gov/pubmed/21997136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.397
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