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Irinotecan metabolite SN38 results in germ cell loss in the testis but not in the ovary of prepubertal mice
STUDY QUESTION: Does the Irinotecan metabolite 7-ethyl-10-hydroxycamptothecan (SN38) damage the gonads of male and female prepubertal mice? SUMMARY ANSWER: The Irinotecan metabolite SN38 reduces germ cell numbers within the seminiferous tubules of mouse testes at concentrations that are relevant to...
Shranjeno v:
| izdano v: | Mol Hum Reprod |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5099998/ https://ncbi.nlm.nih.gov/pubmed/27470502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaw051 |
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