Herpes Simplex Virus 1 UL24 Abrogates the DNA Sensing Signal Pathway by Inhibiting NF-κB Activation

Cyclic GMP-AMP synthase (cGAS) is a newly identified DNA sensor that recognizes foreign DNA, including the genome of herpes simplex virus 1 (HSV-1). Upon binding of viral DNA, cGAS produces cyclic GMP-AMP, which interacts with and activates stimulator of interferon genes (STING) to trigger the trans...

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Vydáno v:J Virol
Hlavní autoři: Xu, Haiyan, Su, Chenhe, Pearson, Angela, Mody, Christopher H., Zheng, Chunfu
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Virus-Cell Interactions
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355614/
https://ncbi.nlm.nih.gov/pubmed/28100608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00025-17
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