Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize that unraveling the mechanisms of pathway cross-talk will be useful for designing novel co-targeting strategies for ovarian cancer (OC...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Wagner, Renate, Stübiger, Gerald, Veigel, Daniel, Wuczkowski, Michael, Lanzerstorfer, Peter, Weghuber, Julian, Karteris, Emmanouil, Nowikovsky, Karin, Wilfinger-Lutz, Nastasia, Singer, Christian F., Colomer, Ramón, Benhamú, Bellinda, López-Rodríguez, María Luz, Valent, Peter, Grunt, Thomas W.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355289/
https://ncbi.nlm.nih.gov/pubmed/28086243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14591
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