Metformin promotes apoptosis in hepatocellular carcinoma through the CEBPD-induced autophagy pathway

Metformin, as an AMP-activated protein kinase (AMPK) activator, can activate autophagy. A study showed that metformin decreased the risk of hepatocellular carcinoma (HCC) in diabetic patients. However, the detailed mechanism in the metformin-mediated anticancer effect remains an open question. Trans...

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Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Oncotarget
Hauptverfasser: Tsai, Hsin-Hwa, Lai, Hong-Yue, Chen, Yueh-Chiu, Li, Chien-Feng, Huang, Huei-Sheng, Liu, Hsiao-Sheng, Tsai, Yau-Sheng, Wang, Ju-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5355142/
https://ncbi.nlm.nih.gov/pubmed/28099155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14640
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