Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

Small molecule inhibitors of pre-mRNA splicing are important tools for identifying new spliceosome assembly intermediates, allowing a finer dissection of spliceosome dynamics and function. Here, we identified a small molecule that inhibits human pre-mRNA splicing at an intermediate stage during conv...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Sidarovich, Anzhalika, Will, Cindy L, Anokhina, Maria M, Ceballos, Javier, Sievers, Sonja, Agafonov, Dmitry E, Samatov, Timur, Bao, Penghui, Kastner, Berthold, Urlaub, Henning, Waldmann, Herbert, Lührmann, Reinhard
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2017
Assuntos:
Biochemistry
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354520/
https://ncbi.nlm.nih.gov/pubmed/28300534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23533
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