Antibody Neutralization of CXCL10 in Vivo Is Dependent on Binding to Free and Not Endothelial-bound Chemokine: IMPLICATIONS FOR THE DESIGN OF A NEW GENERATION OF ANTI-CHEMOKINE THERAPEUTIC ANTIBODIES

To improve our understanding of properties that confer successful inhibition of chemokines in vivo, we analyzed anti-murine CXCL10 monoclonal antibodies (mAb) having different characteristics. 1B6 displayed potent inhibition of cell recruitment in vitro with an IC(50) of 0.5 nm but demonstrated litt...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Bonvin, Pauline, Gueneau, Franck, Buatois, Vanessa, Charreton-Galby, Maud, Lasch, Stanley, Messmer, Marie, Christen, Urs, Luster, Andrew D., Johnson, Zoë, Ferlin, Walter, Kosco-Vilbois, Marie, Proudfoot, Amanda, Fischer, Nicolas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354510/
https://ncbi.nlm.nih.gov/pubmed/28154179
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.745877
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