Green Tea Polyphenol Epigallocatechin-3-gallate Suppresses Toll-like Receptor 4 Expression via Up-regulation of E3 Ubiquitin-protein Ligase RNF216

Toll-like receptor 4 (TLR4) plays an essential role in innate immunity through inflammatory cytokine induction. Recent studies demonstrated that the abnormal activation of TLR4 has a pivotal role in obesity-induced inflammation, which is associated with several diseases, including hyperinsulinemia,...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Kumazoe, Motofumi, Nakamura, Yuki, Yamashita, Mai, Suzuki, Takashi, Takamatsu, Kanako, Huang, Yuhui, Bae, Jaehoon, Yamashita, Shuya, Murata, Motoki, Yamada, Shuhei, Shinoda, Yuki, Yamaguchi, Wataru, Toyoda, Yui, Tachibana, Hirofumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354502/
https://ncbi.nlm.nih.gov/pubmed/28154178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.755959
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