The FOXO3/PGC-1β signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma

In 95% of patients with pancreatic ductal adenocarcinoma, recurrence is observed following chemotherapy. Findings from several studies have indicated that cancer stem cells (CSCs) are resistant to anticancer agents and may be involved in cancer recurrence and metastasis. The CD44 protein is a major...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kumazoe, Motofumi, Takai, Mika, Hiroi, Shun, Takeuchi, Chieri, Kadomatsu, Mai, Nojiri, Takashi, Onda, Hiroaki, Bae, Jaehoon, Huang, Yuhui, Takamatsu, Kanako, Yamashita, Shuya, Kangawa, Kenji, Tachibana, Hirofumi
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2017
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5491768/
https://ncbi.nlm.nih.gov/pubmed/28507102
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.772111
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