Cellular Uptake and Delivery of Myeloperoxidase to Lysosomes Promote Lipofuscin Degradation and Lysosomal Stress in Retinal Cells

Neutrophil myeloperoxidase (MPO) catalyzes the H(2)O(2)-dependent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent. Besides its well defined role in innate immunity, aberrant degranulation of neutrophils in several inflammatory diseases leads to redistribution...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Yogalingam, Gouri, Lee, Amanda R., Mackenzie, Donald S., Maures, Travis J., Rafalko, Agnes, Prill, Heather, Berguig, Geoffrey Y., Hague, Chuck, Christianson, Terri, Bell, Sean M., LeBowitz, Jonathan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2017
Schlagworte:
Enzymology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354499/
https://ncbi.nlm.nih.gov/pubmed/28115520
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.739441
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