Cathepsin D Deficiency Induces Lysosomal Storage with Ceroid Lipofuscin in Mouse CNS Neurons

Cathepsin D-deficient (CD−/−) mice have been shown to manifest seizures and become blind near the terminal stage [approximately postnatal day (P) 26]. We therefore examined the morphological, immunocytochemical, and biochemical features of CNS tissues of these mice. By electron microscopy, autophago...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Koike, Masato, Nakanishi, Hiroshi, Saftig, Paul, Ezaki, Junji, Isahara, Kyoko, Ohsawa, Yoshiyuki, Schulz-Schaeffer, Walter, Watanabe, Tsuyoshi, Waguri, Satoshi, Kametaka, Satoshi, Shibata, Masahiro, Yamamoto, Kenji, Kominami, Eiki, Peters, Christoph, von Figura, Kurt, Uchiyama, Yasuo
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2000
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6772823/
https://ncbi.nlm.nih.gov/pubmed/10995834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.20-18-06898.2000
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