Participation of Autophagy in Storage of Lysosomes in Neurons from Mouse Models of Neuronal Ceroid-Lipofuscinoses (Batten Disease)

In cathepsin D-deficient (CD−/−) and cathepsins B and L double-deficient (CB−/−CL−/−) mice, abnormal vacuolar structures accumulate in neurons of the brains. Many of these structures resemble autophagosomes in which part of the cytoplasm is retained but their precise nature and biogenesis remain unk...

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Detalhes bibliográficos
Main Authors: Koike, Masato, Shibata, Masahiro, Waguri, Satoshi, Yoshimura, Kentaro, Tanida, Isei, Kominami, Eiki, Gotow, Takahiro, Peters, Christoph, von Figura, Kurt, Mizushima, Noboru, Saftig, Paul, Uchiyama, Yasuo
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2005
Assuntos:
Original Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1613187/
https://ncbi.nlm.nih.gov/pubmed/16314482
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