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Platelet Factor 4 Binds to Vascular Proteoglycans and Controls Both Growth Factor Activities and Platelet Activation

Platelet factor 4 (PF4) is produced by platelets with roles in both inflammation and wound healing. PF4 is stored in platelet α-granules bound to the glycosaminoglycan (GAG) chains of serglycin. This study revealed that platelet serglycin is decorated with chondroitin/dermatan sulfate and that PF4 b...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Lord, Megan S., Cheng, Bill, Farrugia, Brooke L., McCarthy, Simon, Whitelock, John M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354495/
https://ncbi.nlm.nih.gov/pubmed/28115521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.760660
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