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Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

Transforming growth factor-β (TGF-β) signals through both SMAD and non-SMAD pathways to elicit a wide array of biological effects. Existing data have shown the association and coordination between STATs and SMADs in mediating TGF-β functions in hepatic cells, but it is not clear how STATs are activa...

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Vydáno v:J Biol Chem
Hlavní autoři: Tang, Liu-Ya, Heller, Mary, Meng, Zhaojing, Yu, Li-Rong, Tang, Yi, Zhou, Ming, Zhang, Ying E.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354477/
https://ncbi.nlm.nih.gov/pubmed/28154170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773085
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