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MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes

Homeostasis of Smad phosphorylation at its C-terminal SXS motif is essential for transforming growth factor β (TGFβ) signaling. Whereas it is known that TGFβ signaling can be terminated by phosphatases, which dephosphorylate R-Smads in the nucleus, it is unclear whether there are any cytoplasmic pho...

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Hlavní autoři: Yu, Junjing, Pan, Lei, Qin, Xincheng, Chen, Hua, Xu, Youli, Chen, Yeguang, Tang, Hong
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2832994/
https://ncbi.nlm.nih.gov/pubmed/20061380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.075036
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