Generation of murine tumor cell lines deficient in MHC molecule surface expression using the CRISPR/Cas9 system

In this study, the CRISPR/Cas9 technology was used to establish murine tumor cell lines, devoid of MHC I or MHC II surface expression, respectively. The melanoma cell line B16F10 and the murine breast cancer cell line EO-771, the latter stably expressing the tumor antigen NY-BR-1 (EO-NY), were trans...

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Publicado en:PLoS One
Autores principales: Das, Krishna, Eisel, David, Lenkl, Clarissa, Goyal, Ashish, Diederichs, Sven, Dickes, Elke, Osen, Wolfram, Eichmüller, Stefan B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354463/
https://ncbi.nlm.nih.gov/pubmed/28301575
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174077
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