In vivo and ex vivo cetuximab sensitivity assay using three-dimensional primary culture system to stratify KRAS mutant colorectal cancer

In clinic, cetuximab, an anti-EGFR antibody, improves treatment outcomes in colorectal cancer (CRC). KRAS-mutant CRC is generally resistant to cetuximab, although difference of the sensitivity among KRAS-mutants has not been studied in detail. We previously developed the cancer tissue-originated sph...

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Udgivet i:PLoS One
Main Authors: Tashiro, Takahiro, Okuyama, Hiroaki, Endo, Hiroko, Kawada, Kenji, Ashida, Yasuko, Ohue, Masayuki, Sakai, Yoshiharu, Inoue, Masahiro
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354432/
https://ncbi.nlm.nih.gov/pubmed/28301591
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0174151
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