Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin

Multidrug resistance(MDR) is a major obstacle to efficiency of breast cancer chemotherapy. We investigated whether combination of metformin and 2-deoxyglucose reverses MDR of MCF-7/Dox cells and tried to elucidate the possible mechanisms. The combination of metformin and 2-deoxyglucose selectively e...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xue, Chaojun, Wang, Changyuan, Sun, Yaoting, Meng, Qiang, Liu, Zhihao, Huo, Xiaokui, Sun, Pengyuan, Sun, Huijun, Ma, Xiaodong, Ma, Xiaochi, Peng, Jinyong, Liu, Kexin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352427/
https://ncbi.nlm.nih.gov/pubmed/28052008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14373
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