Dasatinib reverses the multidrug resistance of breast cancer MCF-7 cells to doxorubicin by downregulating P-gp expression via inhibiting the activation of ERK signaling pathway

Multidrug resistance (MDR) is one of the major obstacles to the efficiency of cancer chemotherapy, which often results from the overexpression of drug efflux transporters such as P-glycoprotein (P-gp). In the present study, we determined the effect of dasatinib which was approved for imatinib resist...

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發表在:Cancer Biol Ther
Main Authors: Chen, Ting, Wang, Changyuan, Liu, Qi, Meng, Qiang, Sun, Huijun, Huo, Xiaokui, Sun, Pengyuan, Peng, Jinyong, Liu, Zhihao, Yang, Xiaobo, Liu, Kexin
格式: Artigo
語言:Inglês
出版: Taylor & Francis 2014
主題:
Research Papers
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4622436/
https://ncbi.nlm.nih.gov/pubmed/25482933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384047.2014.987062
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