ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype

Here, we evaluated whether the overexpression of transcriptionally inactive ΔNp73 cooperates with PML/RARA fusion protein in the induction of an APL-leukemic phenotype, as well as its role in vitro in proliferation, myeloid differentiation, and drug-induced apoptosis. Using lentiviral gene transfer,...

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Udgivet i:Oncotarget
Main Authors: Lucena-Araujo, Antonio R., Coelho-Silva, Juan L., Pereira-Martins, Diego A., Thomé, Carolina, Scheucher, Priscila S., Lange, Ana P., Paiva, Helder H., Hemmelgarn, Benjamin T., Morais-Sobral, Mariana C., Azevedo, Elisa A., Franca-Neto, Pedro L., Franca, Rafael F., Silva, Cleide L., Krause, Alexandre, Rego, Eduardo M.
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352415/
https://ncbi.nlm.nih.gov/pubmed/28035072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14295
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