Prospective identification of resistance mechanisms to HSP90 inhibition in KRAS mutant cancer cells

Inhibition of the HSP90 chaperone results in depletion of many signaling proteins that drive tumorigenesis, such as downstream effectors of KRAS, the most commonly mutated human oncogene. As a consequence, several small-molecule HSP90 inhibitors are being evaluated in clinical trials as anticancer a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Oncotarget
Main Authors: Rouhi, Arefeh, Miller, Christina, Grasedieck, Sarah, Reinhart, Stefanie, Stolze, Britta, Döhner, Hartmut, Kuchenbauer, Florian, Bullinger, Lars, Fröhling, Stefan, Scholl, Claudia
Format: Artigo
Jezik:Inglês
Izdano: Impact Journals LLC 2016
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5352352/
https://ncbi.nlm.nih.gov/pubmed/28032595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13841
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