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Comparative analysis of KRAS codon 12, 13, 18, 61, and 117 mutations using human MCF10A isogenic cell lines

KRAS mutations occur in one third of human cancers and cluster in several hotspots, with codons 12 and 13 being most commonly affected. It has been suggested that the position and type of amino acid exchange influence the transforming capacity of mutant KRAS proteins. We used MCF10A human mammary ep...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Stolze, Britta, Reinhart, Stefanie, Bulllinger, Lars, Fröhling, Stefan, Scholl, Claudia
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4336936/
https://ncbi.nlm.nih.gov/pubmed/25705018
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08535
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