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Identification of a novel Polo-like kinase 1 inhibitor that specifically blocks the functions of Polo-Box domain
Polo-like kinase 1 (Plk1) is a promising target for cancer therapy due to its essential role in cell division. In addition to a highly conserved kinase domain, Plk1 also contains a Polo-Box domain (PBD), which is essential for Plk1's subcellular localization and mitotic functions. We adopted a...
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| 出版年: | Oncotarget |
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| 主要な著者: | , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Impact Journals LLC
2016
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5352051/ https://ncbi.nlm.nih.gov/pubmed/27902479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.13603 |
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