Anticancer activity of a novel small molecule tubulin inhibitor STK899704

We have identified the small molecule STK899704 as a structurally novel tubulin inhibitor. STK899704 suppressed the proliferation of cancer cell lines from various origins with IC(50) values ranging from 0.2 to 1.0 μM. STK899704 prevented the polymerization of purified tubulin in vitro and also depo...

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Udgivet i:PLoS One
Main Authors: Sakchaisri, Krisada, Kim, Sun-Ok, Hwang, Joonsung, Soung, Nak Kyun, Lee, Kyung Ho, Choi, Tae Woong, Lee, Yongjun, Park, Chan-Mi, Thimmegowda, Naraganahalli R., Lee, Phil Young, Shwetha, Bettaswamigowda, Srinivasrao, Ganipisetti, Pham, Thi Thu Huong, Jang, Jae-Hyuk, Yum, Hye-Won, Surh, Young-Joon, Lee, Kyung S., Park, Hwangseo, Kim, Seung Jun, Kwon, Yong Tae, Ahn, Jong Seog, Kim, Bo Yeon
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5351965/
https://ncbi.nlm.nih.gov/pubmed/28296906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0173311
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