The Novel Small Molecule STK899704 Promotes Senescence of the Human A549 NSCLC Cells by Inducing DNA Damage Responses and Cell Cycle Arrest

The novel synthetic compound designated STK899704 (PubChem CID: 5455708) suppresses the proliferation of a broad range of cancer cell types. However, the details of its effect on lung cancer cells are unclear. We investigated the precise anticancer effect of STK899704 on senescence and growth arrest...

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Publicat a:Front Pharmacol
Autors principals: Park, Chan-Woo, Bak, Yesol, Kim, Min-Je, Srinivasrao, Ganipisetti, Hwang, Joonsung, Sung, Nak K., Kim, Bo Yeon, Yu, Jae-Hyuk, Hong, Jin Tae, Yoon, Do-Young
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2018
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5912185/
https://ncbi.nlm.nih.gov/pubmed/29713275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2018.00163
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