Bitransgenesis with β(2)‐Adrenergic Receptors or Adenylyl Cyclase Fails to Improve β(1)‐Adrenergic Receptor Cardiomyopathy

Cardiomyopathic effects of β‐adrenergic receptor (βAR) signaling are primarily due to the β(1)AR subtype. β(1)/β(2)AR and β(1)/adenylyl cyclase type 5 (AC5) bitransgenic mice were created to test the hypothesis that β(2)AR or AC5 co‐overexpression has beneficial effects in β(1)AR‐mediated cardiomyop...

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Publicado en:Clin Transl Sci
Autores principales: Petrashevskaya, Natalia, Gaume, Brigitte R., Mihlbachler, Kathryn A., Dorn II, Gerald W., Liggett, Stephen B.
Formato: Artigo
Lenguaje:Inglês
Publicado: Blackwell Publishing Inc 2008
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350669/
https://ncbi.nlm.nih.gov/pubmed/20443853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1752-8062.2008.00061.x
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