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Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: A novel approach to β-adrenergic receptor blockade
β-Adrenergic receptor (β-AR) blockade is widely used to treat heart failure, since the adverse effects of chronic β-AR stimulation are central to the pathogenesis of this disease state. Transgenic (Tg) mice, where β-AR signaling is chronically enhanced by overexpression of cardiac β(2)-ARs, is a sur...
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| Veröffentlicht in: | Am J Physiol Heart Circ Physiol |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Physiological Society
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4233298/ https://ncbi.nlm.nih.gov/pubmed/25193472 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00491.2014 |
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