Fatal Mycobacterium tuberculosis infection despite adaptive immune response in the absence of MyD88

Toll-like receptors (TLRs) such as TLR2 and TLR4 have been implicated in host response to mycobacterial infection. Here, mice deficient in the TLR adaptor molecule myeloid differentiation factor 88 (MyD88) were infected with Mycobacterium tuberculosis (MTB). While primary MyD88(–/–) macrophages and...

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Hlavní autoři: Fremond, Cecile M., Yeremeev, Vladimir, Nicolle, Delphine M., Jacobs, Muazzam, Quesniaux, Valerie F., Ryffel, Bernhard
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Clinical Investigation 2004
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC535064/
https://ncbi.nlm.nih.gov/pubmed/15599404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200421027
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