Molecular role of the PAX5‐ETV6 oncoprotein in promoting B‐cell acute lymphoblastic leukemia

PAX5 is a tumor suppressor in B‐ALL, while the role of PAX5 fusion proteins in B‐ALL development is largely unknown. Here, we studied the function of PAX5‐ETV6 and PAX5‐FOXP1 in mice expressing these proteins from the Pax5 locus. Both proteins arrested B‐lymphopoiesis at the pro‐B to pre‐B‐cell tran...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Smeenk, Leonie, Fischer, Maria, Jurado, Sabine, Jaritz, Markus, Azaryan, Anna, Werner, Barbara, Roth, Mareike, Zuber, Johannes, Stanulla, Martin, den Boer, Monique L, Mullighan, Charles G, Strehl, Sabine, Busslinger, Meinrad
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350564/
https://ncbi.nlm.nih.gov/pubmed/28219927
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201695495
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