The role of the Janus-faced transcription factor PAX5-JAK2 in acute lymphoblastic leukemia

PAX5-JAK2 has recently been identified as a novel recurrent fusion gene in B-cell precursor acute lymphoblastic leukemia, but the function of the encoded chimeric protein has not yet been characterized in detail. Herein we show that the PAX5-JAK2 chimera, which consists of the DNA-binding paired dom...

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Udgivet i:Blood
Main Authors: Schinnerl, Dagmar, Fortschegger, Klaus, Kauer, Maximilian, Marchante, João R. M., Kofler, Reinhard, Den Boer, Monique L., Strehl, Sabine
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2015
Fag:
Lymphoid Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375719/
https://ncbi.nlm.nih.gov/pubmed/25515960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-04-570960
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