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Hsp70 displaces small heat shock proteins from aggregates to initiate protein refolding

Small heat shock proteins (sHsps) are an evolutionary conserved class of ATP‐independent chaperones that protect cells against proteotoxic stress. sHsps form assemblies with aggregation‐prone misfolded proteins, which facilitates subsequent substrate solubilization and refolding by ATP‐dependent Hsp...

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Bibliografske podrobnosti
izdano v:EMBO J
Main Authors: Żwirowski, Szymon, Kłosowska, Agnieszka, Obuchowski, Igor, Nillegoda, Nadinath B, Piróg, Artur, Ziętkiewicz, Szymon, Bukau, Bernd, Mogk, Axel, Liberek, Krzysztof
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350560/
https://ncbi.nlm.nih.gov/pubmed/28219929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593378
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