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Osteoblastic Lrp4 promotes osteoclastogenesis by regulating ATP release and adenosine-A(2A)R signaling
Bone homeostasis depends on the functional balance of osteoblasts (OBs) and osteoclasts (OCs). Lrp4 is a transmembrane protein that is mutated in patients with high bone mass. Loss of Lrp4 in OB-lineage cells increases bone mass by elevating bone formation by OBs and reducing bone resorption by OCs....
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| Publicado no: | J Cell Biol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5350517/ https://ncbi.nlm.nih.gov/pubmed/28193701 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201608002 |
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