Swedish Mutant APP Suppresses Osteoblast Differentiation and Causes Osteoporotic Deficit, Which Are Ameliorated by N-Acetyl-L-Cysteine

Reduced bone mineral density and hip fracture are frequently observed in patients with Alzheimer’s disease (AD). However, mechanisms underlying their association remain poorly understood. Amyloid precursor protein (APP) is a transmembrane protein that is ubiquitously expressed in bone marrow stromal...

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Detalhes bibliográficos
Publicado no:J Bone Miner Res
Main Authors: Xia, Wen-Fang, Jung, Ji-Ung, Shun, Cui, Xiong, Shan, Xiong, Lei, Shi, Xing-Ming, Mei, Lin, Xiong, Wen-Cheng
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7104794/
https://ncbi.nlm.nih.gov/pubmed/23649480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jbmr.1954
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