Inhibition of MAPK‐Erk pathway in vivo attenuates aortic valve disease processes in Emilin1‐deficient mouse model

Aortic valve disease (AVD) is a common condition with a progressive natural history, and presently, there are no pharmacologic treatment strategies. Elastic fiber fragmentation (EFF) is a hallmark of AVD, and increasing evidence implicates developmental elastic fiber assembly defects. Emilin1 is a g...

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Vydáno v:Physiol Rep
Hlavní autoři: Munjal, Charu, Jegga, Anil G., Opoka, Amy M., Stoilov, Ivan, Norris, Russell A., Thomas, Craig J., Smith, J. Michael, Mecham, Robert P., Bressan, Giorgio M., Hinton, Robert B.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2017
Témata:
Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5350168/
https://ncbi.nlm.nih.gov/pubmed/28270590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14814/phy2.13152
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