Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain

Ischemic stroke results in excessive release of glutamate, which contributes to neuronal cell death. Here, we test the hypothesis that otherwise neurotoxic glutamate can be productively metabolized by glutamate oxaloacetate transaminase (GOT) to maintain cellular energetics and protect the brain fro...

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Publicat a:FASEB J
Autors principals: Rink, Cameron, Gnyawali, Surya, Stewart, Richard, Teplitsky, Seth, Harris, Hallie, Roy, Sashwati, Sen, Chandan K., Khanna, Savita
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2017
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349801/
https://ncbi.nlm.nih.gov/pubmed/28096234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601033R
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