Oxygen-Inducible Glutamate Oxaloacetate Transaminase as Protective Switch Transforming Neurotoxic Glutamate to Metabolic Fuel During Acute Ischemic Stroke

This work rests on our previous report (J Cereb Blood Flow Metab 30: 1275–1287, 2010) recognizing that glutamate (Glu) oxaloacetate transaminase (GOT) is induced when brain tissue hypoxia is corrected during acute ischemic stroke (AIS). GOT can metabolize Glu into tricarboxylic acid cycle intermedia...

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Autori principali: Rink, Cameron, Gnyawali, Surya, Peterson, Laura, Khanna, Savita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2011
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Original Research Communication
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3078502/
https://ncbi.nlm.nih.gov/pubmed/21361730
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2011.3930
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