Glutamate oxaloacetate transaminase enables anaplerotic refilling of TCA cycle intermediates in stroke-affected brain

Ischemic stroke results in excessive release of glutamate, which contributes to neuronal cell death. Here, we test the hypothesis that otherwise neurotoxic glutamate can be productively metabolized by glutamate oxaloacetate transaminase (GOT) to maintain cellular energetics and protect the brain fro...

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Veröffentlicht in:FASEB J
Hauptverfasser: Rink, Cameron, Gnyawali, Surya, Stewart, Richard, Teplitsky, Seth, Harris, Hallie, Roy, Sashwati, Sen, Chandan K., Khanna, Savita
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2017
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349801/
https://ncbi.nlm.nih.gov/pubmed/28096234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601033R
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