Excessive α-tocopherol exacerbates microglial activation and brain injury caused by acute ischemic stroke

The vitamin E family includes both tocopherols and tocotrienols, where α-tocopherol (αTOC) is the most bioavailable form. Clinical trials testing the therapeutic efficacy of high-dose αTOC against stroke have largely failed or reported negative outcomes when a “more is better” approach to supplement...

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Udgivet i:FASEB J
Main Authors: Khanna, Savita, Heigel, Mallory, Weist, Jessica, Gnyawali, Surya, Teplitsky, Seth, Roy, Sashwati, Sen, Chandan K., Rink, Cameron
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2015
Fag:
Research Communication
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4763884/
https://ncbi.nlm.nih.gov/pubmed/25411436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.14-263723
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