Mechanosensitive transient receptor potential vanilloid 4 regulates Dermatophagoides farinae–induced airway remodeling via 2 distinct pathways modulating matrix synthesis and degradation

Contributions of mechanical signals to airway remodeling during asthma are poorly understood. Transient receptor potential vanilloid 4 (TRPV4), a mechanosensitive ion channel, has been implicated in cardiac and pulmonary fibrosis; however, its role in asthma remains elusive. Employing a Dermatophago...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Gombedza, Farai, Kondeti, Vinay, Al-Azzam, Nosayba, Koppes, Stephanie, Duah, Ernest, Patil, Prachi, Hexter, Madison, Phillips, Daniel, Thodeti, Charles K., Paruchuri, Sailaja
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349793/
https://ncbi.nlm.nih.gov/pubmed/28073835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201601045R
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