Mecp2-mediated Epigenetic Silencing of miR-137 Contributes to Colorectal Adenoma-Carcinoma Sequence and Tumor Progression via Relieving the Suppression of c-Met

The molecular mechanisms underlying colorectal cancer (CRC) development remain elusive. In this study, we examined the miRNA and mRNA expressions in the adenoma-carcinoma sequence (ACS), a critical neoplastic progression in CRC development. We found that miR-137 was down-regulated in all adenoma and...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Tao, Cai, Shi-Lun, Li, Jian, Qi, Zhi-Peng, Li, Xu-Quan, Ye, Le-Chi, Xie, Xiao-Feng, Hou, Ying-Yong, Yao, Li-Qing, Xu, Mei-Dong, Zhou, Ping-Hong, Xu, Jian-Min, Zhong, Yun-Shi
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349564/
https://ncbi.nlm.nih.gov/pubmed/28291253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep44543
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