Epigenetic silencing of microRNA-137 enhances ASCT2 expression and tumor glutamine metabolism

Tumor cells must activate specific transporters to meet their increased glutamine metabolic demands. Relative to other glutamine transporters, the ASC family transporter 2 (ASCT2, also called SLC1A5) is profoundly elevated in a wide spectrum of human cancers to coordinate metabolic reprogramming and...

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Detalhes bibliográficos
Publicado no:Oncogenesis
Main Authors: Dong, J, Xiao, D, Zhao, Z, Ren, P, Li, C, Hu, Y, Shi, J, Su, H, Wang, L, Liu, H, Li, B, Gao, P, Qing, G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541711/
https://ncbi.nlm.nih.gov/pubmed/28692032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/oncsis.2017.59
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