Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Defects in mitochondrial biogenesis and function are common in many neurodegenerative disorders, including Huntington’s disease (HD). We have previously shown that in yeast models of HD, enhancement of mitochondrial biogenesis through overexpression of Hap4, the catalytic subunit of the transcriptio...

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Publicat a:Microb Cell
Autors principals: Ruetenik, Andrea L., Ocampo, Alejandro, Ruan, Kai, Zhu, Yi, Li, Chong, Zhai, R. Grace, Barrientos, Antoni
Format: Artigo
Idioma:Inglês
Publicat: Shared Science Publishers OG 2016
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5349013/
https://ncbi.nlm.nih.gov/pubmed/28357370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15698/mic2016.08.518
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