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Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects
BACKGROUND: Protein aggregation and its pathological effects are the major cause of several neurodegenerative diseases. In Huntington’s disease an elongated stretch of polyglutamines within the protein Huntingtin leads to increased aggregation propensity. This induces cellular defects, culminating i...
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| Publicado no: | BMC Genomics |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4558792/ https://ncbi.nlm.nih.gov/pubmed/26335097 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1831-7 |
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