Polyglutamine toxicity in yeast induces metabolic alterations and mitochondrial defects

BACKGROUND: Protein aggregation and its pathological effects are the major cause of several neurodegenerative diseases. In Huntington’s disease an elongated stretch of polyglutamines within the protein Huntingtin leads to increased aggregation propensity. This induces cellular defects, culminating i...

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Bibliografiset tiedot
Julkaisussa:BMC Genomics
Päätekijät: Papsdorf, Katharina, Kaiser, Christoph J. O., Drazic, Adrian, Grötzinger, Stefan W., Haeßner, Carmen, Eisenreich, Wolfgang, Richter, Klaus
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2015
Aiheet:
Research Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4558792/
https://ncbi.nlm.nih.gov/pubmed/26335097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-015-1831-7
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