Attenuation of polyglutamine-induced toxicity by enhancement of mitochondrial OXPHOS in yeast and fly models of aging

Defects in mitochondrial biogenesis and function are common in many neurodegenerative disorders, including Huntington’s disease (HD). We have previously shown that in yeast models of HD, enhancement of mitochondrial biogenesis through overexpression of Hap4, the catalytic subunit of the transcriptio...

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Detalhes bibliográficos
Main Authors: Andrea L. Ruetenik, Alejandro Ocampo, Morgan L. McCarthy, Kai Ruan, Yi Zhu, Chong Li, R. Grace Zhai, Antoni Barrientos
Formato: Artigo
Idioma:Inglês
Publicado em: Shared Science Publishers OG 2016-07-01
Colecção:Microbial Cell
Assuntos:
Saccharomyces cerevisiae
mitochondrial respiration
mitochondrial OXPHOS
mitochondrial biogenesis
polyglutamine toxicity
yeast chronological life span
Drosophila model
caloric restriction
Acesso em linha:http://microbialcell.com/researcharticles/attenuation-of-polyglutamine-induced-toxicity-by-enhancement-of-mitochondrial-oxphos-in-yeast-and-fly-models-of-aging/
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