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Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Lifespan and its Extension by Caloric Restriction

We have explored the role of mitochondrial function in aging by genetically and pharmacologically modifying yeast cellular respiration production during the exponential and/or stationary growth phases, and determining how this affects chronological lifespan (CLS). Our results demonstrate that respir...

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Detalhes bibliográficos
Main Authors: Ocampo, Alejandro, Liu, Jingjing, Schroeder, Elizabeth A., Shadel, Gerald S., Barrientos, Antoni
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397320/
https://ncbi.nlm.nih.gov/pubmed/22768839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.05.013
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