Mitochondrial Respiratory Thresholds Regulate Yeast Chronological Lifespan and its Extension by Caloric Restriction

We have explored the role of mitochondrial function in aging by genetically and pharmacologically modifying yeast cellular respiration production during the exponential and/or stationary growth phases, and determining how this affects chronological lifespan (CLS). Our results demonstrate that respir...

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Main Authors: Ocampo, Alejandro, Liu, Jingjing, Schroeder, Elizabeth A., Shadel, Gerald S., Barrientos, Antoni
Format: Artigo
Jezik:Inglês
Izdano: 2012
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3397320/
https://ncbi.nlm.nih.gov/pubmed/22768839
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2012.05.013
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