Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

Eighteen variants recovered from specific locus mutation rate experiments involving the mutagen chlorambucil were subjected to several genetic and molecular analyses. Most mutations were found to be homozygous lethal. Because lethality is often presumptive evidence for multilocus-deletion events, 10...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Rinchik, E M, Bangham, J W, Hunsicker, P R, Cacheiro, N L, Kwon, B S, Jackson, I J, Russell, L B
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53486/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2304907/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.4.1416
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