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Genetic and molecular analysis of chlorambucil-induced germ-line mutations in the mouse.

Eighteen variants recovered from specific locus mutation rate experiments involving the mutagen chlorambucil were subjected to several genetic and molecular analyses. Most mutations were found to be homozygous lethal. Because lethality is often presumptive evidence for multilocus-deletion events, 10...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Rinchik, E M, Bangham, J W, Hunsicker, P R, Cacheiro, N L, Kwon, B S, Jackson, I J, Russell, L B
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC53486/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2304907/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.4.1416
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